Platelet secretory products may contribute to neuronal injury. | Zendy

R Joseph | Zendy; Chock Tsering | Zendy; S. Grunfeld | Zendy; K.M.A. Welch | Zendy

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Platelet secretory products may contribute to neuronal injury.

Author(s) -

R Joseph,

Chock Tsering,

S. Grunfeld,

K.M.A. Welch

Publication year - 1991

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.22.11.1448

Subject(s) - platelet , medicine , thrombus , neurotoxicity , gliosis , glutamate receptor , stroke (engine) , spinal cord , central nervous system , serotonin , neuroscience , pharmacology , pathology , biology , toxicity , mechanical engineering , receptor , psychiatry , engineering

We do not fully understand the mechanisms for neuronal damage following cerebral arterial occlusion by a thrombus that consists mainly of platelets. The view that certain endogenous substances, such as glutamate, may also contribute to neuronal injury is now reasonably well established. Blood platelets are known to contain and secrete a number of substances that have been associated with neuronal dysfunction. Therefore, we hypothesize that a high concentration (approximately several thousand-fold higher than in plasma, in our estimation) of locally released platelet secretory products derived from the causative thrombus may contribute to neuronal injury and promote reactive gliosis.

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