Tolerance of low cerebral intracellular pH in rats during hyperbaric hypercapnia. | Zendy

Yan Xu | Zendy; Yoram Cohen | Zendy; Lawrence Litt | Zendy; L.H. Chang | Zendy; T. L. James | Zendy

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Tolerance of low cerebral intracellular pH in rats during hyperbaric hypercapnia.

Author(s) -

Yan Xu,

Yoram Cohen,

Lawrence Litt,

L.H. Chang,

T. L. James

Publication year - 1991

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.22.10.1303

Subject(s) - intracellular ph , hypercapnia , medicine , acidosis , intracellular , in vivo , cerebral blood flow , anesthesia , pco2 , biochemistry , chemistry , biology , microbiology and biotechnology

Brain acidosis from cerebral ischemia is characterized by average intracellular pH levels of approximately 5.8-6.2, which appear in turn to worsen cellular injury. We report that the brain is not injured when hypercapnia is used to reduce intracellular pH to about 6.2 during adequate oxygenation. A hyperbaric chamber is needed to achieve intracellular pH values so low because inspired CO2 tensions must be increased to approximately 1 atm.

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