Protective effect of flunarizine on blood-brain barrier permeability alterations in acutely hypertensive rats. | Zendy

Sukriti Nag | Zendy

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Protective effect of flunarizine on blood-brain barrier permeability alterations in acutely hypertensive rats.

Author(s) -

Sukriti Nag

Publication year - 1991

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.22.10.1265

Subject(s) - evans blue , flunarizine , medicine , extravasation , calcium channel blocker , vascular permeability , blood–brain barrier , endocrinology , albumin , permeability (electromagnetism) , calcium , pharmacology , central nervous system , pathology , biochemistry , chemistry , membrane

Increased cerebrovascular permeability to protein is a well-documented finding in acute and chronic hypertension. In this study, we examined the effect of pretreatment with a calcium entry blocker, flunarizine, on the increased cerebrovascular permeability to protein that develops in norepinephrine-induced acute hypertension.

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