A novel treatment for ischemic intracranial hypertension in cats. | Zendy

Rodney Bell | Zendy; Glenn Frazer | Zendy; Jewell L. Osterholm | Zendy; Serge Duckett | Zendy

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A novel treatment for ischemic intracranial hypertension in cats.

Author(s) -

Rodney Bell,

Glenn Frazer,

Jewell L. Osterholm,

Serge Duckett

Publication year - 1991

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.22.1.80

Subject(s) - medicine , cats , intracranial pressure , perfusion , cerebral perfusion pressure , anesthesia , ischemia , cerebral edema , torr , emulsion , cardiology , chemistry , thermodynamics , biochemistry , physics

There is no accepted efficacious treatment for ischemic cerebral edema. We show in a cat model of focal cerebral ischemia that infarct volume can be reduced (p less than 0.05) by ventriculocisternal perfusion with an oxygenated fluorochemical emulsion (bis-perfluorobutylethylene). An accompanying effect of such ventriculocisternal perfusion is a reduction in intracranial pressure. At 18 hours following the start of the perfusion, there was a significant (p less than 0.05) difference in intracranial pressure between nonperfused controls (mean 11.4 [range 2.3-23.0] torr, n = 6) and cats perfused with an oxygenated nutrient solution not containing fluorochemical (mean 11.3 [range 3.0-29.0] torr, n = 8) or animals perfused with the oxygenated fluorochemical emulsion (mean 2.21 [range 0-3.5] torr, n = 7). Perfusion with this oxygenated fluorochemical emulsion warrants further study as a treatment for elevated intracranial pressure.

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