Xenon-enhanced computed tomography compared with [14C]iodoantipyrine for normal and low cerebral blood flow states in baboons. | Zendy

Sidney K. Wolfson | Zendy; Joni Clark | Zendy; Joel Greenberg | Zendy; D Gur | Zendy; Howard Yonas | Zendy; Richard P. Brenner | Zendy; E.E. Cook | Zendy; Patricia A. Lordeon | Zendy

Open Access

Xenon-enhanced computed tomography compared with [14C]iodoantipyrine for normal and low cerebral blood flow states in baboons.

Author(s) -

Sidney K. Wolfson,

Joni Clark,

Joel Greenberg,

D Gur,

Howard Yonas,

Richard P. Brenner,

E.E. Cook,

Patricia A. Lordeon

Publication year - 1990

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.21.5.751

Subject(s) - cerebral blood flow , medicine , baboon , xenon , nuclear medicine , computed tomographic , blood flow , spearman's rank correlation coefficient , correlation , computed tomography , cardiology , radiology , physics , statistics , geometry , mathematics , atomic physics

The correlation between the acute, invasive diffusible [14C]iodoantipyrine technique for cerebral blood flow and the noninvasive xenon-enhanced computed tomographic method has been assessed by simultaneous measurements in the baboon. Blood flows in small tissue volumes (about 0.125 cm3) were directly compared in normal and low flow states. These studies demonstrate a statistically significant association between the two methods (p less than 0.001). Similar correlations were obtained by both the Kendall (tau) and the Spearman (r) methods (r = 0.67 to 0.92, n greater than or equal to 19 for each study). The problems and limitations of such correlations are discussed.

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