Circadian variation in the frequency of ischemic stroke. | Zendy

C. Argentino | Zendy; Danilo Toni | Zendy; Maurizia Rasura | Zendy; Francesco Violi | Zendy; Maria Luisa Sacchetti | Zendy; A. Allegretta | Zendy; F Balsano | Zendy; C. Fieschi | Zendy

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Circadian variation in the frequency of ischemic stroke.

Author(s) -

C. Argentino,

Danilo Toni,

Maurizia Rasura,

Francesco Violi,

Maria Luisa Sacchetti,

A. Allegretta,

F Balsano,

C. Fieschi

Publication year - 1990

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.21.3.387

Subject(s) - medicine , stroke (engine) , cardiology , circadian rhythm , noon , ischemic stroke , ischemia , anesthesia , mechanical engineering , physics , astronomy , engineering

The frequency of myocardial infarction and sudden death is increased between 6 AM and noon. To determine whether the same is true for the onset of ischemic stroke, we studied 426 consecutive patients within 12 hours after the onset of their first hemispheric stroke. The frequency of onset of hemispheric stroke was significantly (p = 0.0001) higher from 6:01 AM to noon (56.1%) than from 12:01 PM to 6 PM (20.2%), from 6:01 PM to midnight (8.2%), and from 12:01 AM to 6 AM (15.5%). The identification of periods of high risk for vascular events may have important therapeutic implications, such as matching drug effects with vulnerability.

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