Baclofen does not protect against cerebral ischemia in rats. | Zendy

Daniel M. Rosenbaum | Zendy; James C. Grotta | Zendy; L. Creed Pettigrew | Zendy; Peter T. Ostrow | Zendy; Roger Strong | Zendy; Howard M. Rhoades | Zendy; C. M. Picone | Zendy; A T Grotta | Zendy

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Baclofen does not protect against cerebral ischemia in rats.

Author(s) -

Daniel M. Rosenbaum,

James C. Grotta,

L. Creed Pettigrew,

Peter T. Ostrow,

Roger Strong,

Howard M. Rhoades,

C. M. Picone,

A T Grotta

Publication year - 1990

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.21.1.138

Subject(s) - medicine , baclofen , ischemia , glutamate receptor , anesthesia , hippocampal formation , pharmacology , nmda receptor , neuroprotection , extracellular , neuronal damage , neuroscience , cardiology , receptor , agonist , biology , biochemistry

Presynaptic release of glutamate into the extracellular compartment and activation of receptor-operated calcium channels may contribute to ischemic neuronal damage. We evaluated the effect of baclofen, a selective inhibitor of presynaptic glutamate release, on mortality, working memory, and light microscopic hippocampal and cortical damage in the four-vessel occlusion model of cerebral ischemia using 64 male Wistar rats. Baclofen (10 mg/kg i.p.) given 1 hour before and 30-60 minutes after 20 minutes of global ischemia did not lessen mortality, prevent ischemic cellular damage, or significantly improve working memory compared with no treatment. We conclude that preischemic and postischemic administration of baclofen does not protect neurons from ischemic injury.

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