Action of magnesium sulfate in the treatment of preeclampsia-eclampsia. | Zendy

Menachem Sadeh | Zendy

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Action of magnesium sulfate in the treatment of preeclampsia-eclampsia.

Author(s) -

Menachem Sadeh

Publication year - 1989

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.20.9.1273

Subject(s) - medicine , eclampsia , vasospasm , magnesium , ischemia , preeclampsia , subarachnoid hemorrhage , cerebral vasospasm , anesthesia , calcium , stroke (engine) , pathogenesis , constriction , cardiology , pregnancy , mechanical engineering , genetics , materials science , engineering , metallurgy , biology

Recent evidence supports the concept that cerebral vasospasm is involved in the pathogenesis of eclampsia. Magnesium, which has a beneficial effect in eclampsia, may act by opposing calcium-dependent arterial constriction, thereby relieving vasospasm. Magnesium may also antagonize the increase in intracellular calcium concentration caused by ischemia and thus prevent cell damage and death. Magnesium might have a role in the treatment of cerebral vasospasm and ischemia, such as occurs in subarachnoid hemorrhage, ischemic stroke, and brain trauma.

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