Role for gamma-aminobutyric acid in selective vulnerability in gerbils. | Zendy

Linda Sternau | Zendy; W. David Lust | Zendy; Anthony J. Ricci | Zendy; Robert A. Ratcheson | Zendy

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Role for gamma-aminobutyric acid in selective vulnerability in gerbils.

Author(s) -

Linda Sternau,

W. David Lust,

Anthony J. Ricci,

Robert A. Ratcheson

Publication year - 1989

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.20.2.281

Subject(s) - gerbil , medicine , neuroprotection , gabaergic , ischemia , hippocampus , inhibitory postsynaptic potential , pharmacology , neuroscience , neurotransmission , anesthesia , receptor , biology

We tested the efficacy of various putative neuroprotective agents in the gerbil model of delayed neuronal death. The selective loss of anterior CA1 neurons of the hippocampus 4 days after 5 minutes of bilateral ischemia was complete in greater than 90% of the gerbils examined. We tested 11 agents for their ability to protect against neuronal loss. Only those agents that were associated with the GABAergic system exhibited protection and only when administered before the ischemic insult. The possibility that delayed neuronal death is the result of a primary defect in inhibitory neurotransmission is considered.

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