Open AccessAntifibrinolytic Activity During Administration of Epsilon-Aminocaproic Acid
Author(s) -
Donald W. Nibbelink
Publication year - 1971
Publication title -
stroke
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.397
H-Index - 319
eISSN - 1524-4628
pISSN - 0039-2499
DOI - 10.1161/01.str.2.6.555
Subject(s) - antifibrinolytic , medicine , aminocaproic acid , epsilon aminocaproic acid , pharmacology , anesthesia , tranexamic acid , surgery , blood loss
Utilizing an in vitro method for activated and nonactivated whole blood clotlysis determinations, the antifibrinolytic effect of epsilon-aminocaproic acid therapy was evaluated. Initially, the induced antifibrinolytic activity diminished within two hours after the previous dose. Continuing therapy for three to six days resulted in sustained fibrinolytic inhibition.
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