Effect of nimodipine on blood pressure in acute ischemic stroke in humans. | Zendy

S. C. Fagan | Zendy; F M Gengo | Zendy; Victoria Bates | Zendy; Steven R. Levine | Zendy; William R. Kinkel | Zendy

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Effect of nimodipine on blood pressure in acute ischemic stroke in humans.

Author(s) -

S. C. Fagan,

F M Gengo,

Victoria Bates,

Steven R. Levine,

William R. Kinkel

Publication year - 1988

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.19.3.401

Subject(s) - nimodipine , medicine , blood pressure , placebo , anesthesia , stroke (engine) , acute stroke , calcium , mechanical engineering , alternative medicine , pathology , tissue plasminogen activator , engineering

Nimodipine is currently under investigation for the treatment of acute stroke. Although relatively specific for the cerebrovasculature, acute reductions in blood pressure after a dose may adversely affect neurologic outcome. We studied 29 consecutive acute ischemic stroke patients treated with placebo (n = 9) or either 120 (n = 10) or 240 (n = 10) mg/day of nimodipine. Blood pressure was recorded before and 30 and 60 minutes after a dose for the first 8 days. Ten neurologic physicians were asked to predict the treatment group (placebo or drug) of randomly selected patients based on blood pressure results. Only those patients on 240 mg/day of nimodipine had significant decreases in blood pressure after a dose (p less than 0.001); however, these were minimal (average 10 mm Hg systolic). Only 26 of 48 treatment predictions (54%) were correct. At the studied doses, nimodipine has a minimal effect on blood pressure in the acute stroke period.

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