Glycerol and dextran combined in the therapy of acute stroke. A placebo-controlled, double-blind trial with a planned interim analysis. | Zendy

Anja Frei | Zendy; C Cottier | Zendy; P Wunderlich | Zendy; Edward N. Ludin | Zendy

Open Access

Glycerol and dextran combined in the therapy of acute stroke. A placebo-controlled, double-blind trial with a planned interim analysis.

Author(s) -

Anja Frei,

C Cottier,

P Wunderlich,

Edward N. Ludin

Publication year - 1987

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.18.2.373

Subject(s) - medicine , placebo , interim analysis , interim , clinical trial , glycerol , anesthesia , stroke (engine) , acute stroke , surgery , mechanical engineering , chemistry , alternative medicine , archaeology , organic chemistry , pathology , tissue plasminogen activator , engineering , history

The results of clinical trials investigating various therapies in acute ischemic stroke have been inconsistent. The effect of glycerol therapy and a combination therapy of glycerol and dextran was evaluated in a double-blind, placebo-controlled study. Repeated neurologic examinations (Day 0, Weeks 1, 6, 12, and 24) according to a modified Mathew score were performed on 62 patients. Statistical analysis showed no superiority of either treatment compared with placebo in acute ischemic stroke. A retrospective estimation of the Type II error of the study yielded approximately p = 0.25. A major side effect was hemolysis in 98% of patients treated with glycerol.

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