Subarachnoid hemorrhage and granulomatous angiitis of the basilar artery: demonstration of the varicella-zoster-virus in the basilar artery lesions. | Zendy

Shunsuke Fukumoto | Zendy; Mitsuru Kinjo | Zendy; Kazuya Hokamura | Zendy; Kentaro Tanaka | Zendy

Open Access

Subarachnoid hemorrhage and granulomatous angiitis of the basilar artery: demonstration of the varicella-zoster-virus in the basilar artery lesions.

Author(s) -

Shunsuke Fukumoto,

Mitsuru Kinjo,

Kazuya Hokamura,

Kentaro Tanaka

Publication year - 1986

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.17.5.1024

Subject(s) - medicine , basilar artery , subarachnoid hemorrhage , varicella zoster virus , pathology , autopsy , giant cell , vasculitis , virus , radiology , virology , surgery , disease

A 70-year-old man, with regional herpes zoster (C2) of 10 weeks duration, died following subarachnoid hemorrhage caused by the rupture of an aneurysm in the basilar artery. Granulomatous angiitis, with multinucleated giant cells, was found at autopsy in the wall of the aneurysm. Electron microscopy of the basilar artery disclosed intracytoplasmic viral particles with an envelope which measured 150-220 nm in diameter. Immunohistochemistry studies revealed varicella-zoster-virus-related antigen in the cytoplasm and/or in the nucleus of histiocytes in the vessel wall. These findings suggest that varicella-zoster virus may be linked to the development of granulomatous angiitis.

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