A dose-escalation study of large doses of naloxone for treatment of patients with acute cerebral ischemia. | Zendy

Harold P. Adams | Zendy; Charles P. Olinger | Zendy; William G. Barsan | Zendy; Michael J. Butler | Zendy; N. R. Graff-Radford | Zendy; Thomas Brott | Zendy; José Biller | Zendy; H Damasio | Zendy; Thomas A. Tomsick | Zendy; Mark P. Goldberg | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

A dose-escalation study of large doses of naloxone for treatment of patients with acute cerebral ischemia.

Author(s) -

Harold P. Adams,

Charles P. Olinger,

William G. Barsan,

Michael J. Butler,

N. R. Graff-Radford,

Thomas Brott,

José Biller,

H Damasio,

Thomas A. Tomsick,

Mark P. Goldberg

Publication year - 1986

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.17.3.404

Subject(s) - medicine , (+) naloxone , anesthesia , bolus (digestion) , ischemia , loading dose , opioid , surgery , cardiology , receptor

A dose-escalation study was performed in 27 patients to determine the highest safe and potentially optimal dose of naloxone for treatment of acute cerebral ischemia. All patients received a bolus of naloxone followed by a continuous 24 hour infusion at an hourly rate 50% of the bolus. Loading doses ranged from 2.5 to 200 mg/m2. Total patient doses ranged from 52.3 to 4978 mg. No major dose-related side effects occurred. This study was not designed to determine naloxone's efficacy in stroke, but transient or sustained improvement was observed in 13 patients. Three patients' neurological condition worsened within three hours after the naloxone was discontinued. Our experience suggests that further therapeutic trials of naloxone are worthwhile.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research