The effects of nifedipine and felodipine on cerebral blood flow during anoxic episodes. | Zendy

John W. Phillis | Zendy; R E DeLong | Zendy; J K Towner | Zendy

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The effects of nifedipine and felodipine on cerebral blood flow during anoxic episodes.

Author(s) -

John W. Phillis,

R E DeLong,

J K Towner

Publication year - 1986

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.17.2.229

Subject(s) - medicine , felodipine , nifedipine , cerebral blood flow , anesthesia , dihydropyridine , blood flow , cerebral circulation , nitrendipine , cardiology , calcium , blood pressure

Cerebral blood flow (CBF) in the rat was monitored by a venous outflow technique with an extracorporeal circulation, which allows for the continuous recording of flow over periods of several hours. Brief periods of anoxia increase the rate of flow. The dihydropyridine calcium antagonists did not affect basal flow rate and depressed the increase in CBF elicited by anoxia. These findings may have significant implications for the therapeutic use of dihydropyridine calcium antagonists in brain ischaemia.

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