Dependence of cerebral arterial contractions on intracellularly stored Ca++. | Zendy

Takaaki Sasaki | Zendy; N F Kassell | Zendy; M Zuccarello | Zendy

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Dependence of cerebral arterial contractions on intracellularly stored Ca++.

Author(s) -

Takaaki Sasaki,

N F Kassell,

M Zuccarello

Publication year - 1986

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.17.1.95

Subject(s) - medicine , cerebral arteries , serotonin , basilar artery , potency , vasoactive , anesthesia , alpha (finance) , prostaglandin , calcium , endocrinology , anatomy , in vitro , surgery , biology , receptor , biochemistry , construct validity , patient satisfaction

The purpose of the present study was to evaluate the dependence of the arterial contractions induced by different vasoactive agents upon intracellularly stored calcium in canine versus monkey cerebral arteries. The potency for inducing contractions in Ca++-free media was in the order of 9,11-epithio-11,12-metano-thromboxane A2 (STXA2) greater than prostaglandin F2 alpha (PGF2 alpha) much greater than serotonin greater than K+ in canine basilar arteries, and STXA2 greater than PGF2 alpha much greater than serotonin = K+ in monkey basilar arteries.

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