Subarachnoid haemorrhage in the rat: effect on the development of cerebral vasospasm of lesions in the central serotoninergic and dopaminergic systems. | Zendy

N. Aa. Svendgaard | Zendy; J. Brismar | Zendy; T. Delgado | Zendy; E. Rosengren | Zendy; Ulf Stenevi | Zendy

Open Access

Subarachnoid haemorrhage in the rat: effect on the development of cerebral vasospasm of lesions in the central serotoninergic and dopaminergic systems.

Author(s) -

N. Aa. Svendgaard,

J. Brismar,

T. Delgado,

E. Rosengren,

Ulf Stenevi

Publication year - 1986

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.17.1.86

Subject(s) - medicine , serotonergic , dopaminergic , vasospasm , subarachnoid hemorrhage , cerebral vasospasm , anesthesia , subarachnoid haemorrhage , dopamine , serotonin , surgery , receptor , aneurysm

In the rat an intracisternal injection of blood induces an angiographically demonstrable biphasic cerebral arterial vasospasm. Chemical destruction of the central serotoninergic and dopaminergic pathways prior to the cisternal blood injection does not affect the spasm pattern after the subarachnoid haemorrhage. It is suggested that neither system plays a role in the development of spasm.

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