Effect of intracarotid hyperosmolar mannitol on cerebral cortical arterioles--a morphometric study. | Zendy

David W. Beck | Zendy; M. N. Hart | Zendy; K. E. Hansen | Zendy

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Effect of intracarotid hyperosmolar mannitol on cerebral cortical arterioles--a morphometric study.

Author(s) -

David W. Beck,

M. N. Hart,

K. E. Hansen

Publication year - 1984

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.15.1.134

Subject(s) - medicine , mannitol , arteriole , vasodilation , lumen (anatomy) , microcirculation , in vivo , anesthesia , caliber , anatomy , cerebral circulation , biology , biochemistry , materials science , microbiology and biotechnology , metallurgy

The morphometric response of cerebral cortical arterioles to intracarotid hyperosmolar mannitol was assessed utilizing a technique of rapid freezing of rat brain tissue in vivo. A significant decrease in the wall to lumen (W/L) ratio was noted in the small parenchymal arterioles (20-49 mu) (p less than .0001) ipsilateral to the mannitol infusion. Larger arterioles showed a decreased W/L ratio but this change was not significant. Control infusion of 0.9% NaCl resulted in no change in arteriolar caliber. These results indicate that intracarotid hyperosmolar mannitol causes a direct vasodilatory response in small cerebral cortical arterioles.

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