Measurement of cerebral blood flow by washout of microwave induced heating. | Zendy

Pablo M. Lawner | Zendy; William H. Oldendorf | Zendy; Leon D. Braun | Zendy

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Measurement of cerebral blood flow by washout of microwave induced heating.

Author(s) -

Pablo M. Lawner,

William H. Oldendorf,

Leon D. Braun

Publication year - 1983

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.14.5.776

Subject(s) - washout , medicine , cerebral blood flow , thermistor , blood flow , microwave , biomedical engineering , cardiology , physics , electrical engineering , quantum mechanics , engineering

A method is described for measurement of cerebral blood flow utilizing the washout of microwave delivered heating. Using a microwave source attenuated to achieve a brain temperature elevation of 0.5-0.75 degrees C after a 2 second exposure in the rat, cerebral blood flow was calculated from the temperature washout curve monitored by a small thermistor implanted in the brain. The results obtained with this method were comparable to those obtained using the [14C] butanol method. To our knowledge this represents the first description of a method to deliver a blood flow "indicator" atraumatically directly into brain tissue.

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