Production of cyclic nucleotides from normal human brain. | Zendy

Etsuo Naito | Zendy; Kosuke Shimoji | Zendy; Hiroomi Endoh | Zendy; Takayoshi Ichikawa | Zendy; M Hashiba | Zendy

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Production of cyclic nucleotides from normal human brain.

Author(s) -

Etsuo Naito,

Kosuke Shimoji,

Hiroomi Endoh,

Takayoshi Ichikawa,

M Hashiba

Publication year - 1983

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.14.3.380

Subject(s) - medicine , nucleotide , cyclic gmp , cyclic nucleotide , venous blood , endocrinology , artery , cardiology , biochemistry , chemistry , nitric oxide , gene

Concentrations of cyclic AMP and cyclic GMP in arterial and internal jugular venous (IJV) blood were determined at the resting wakeful state in thirty surgical patients without neurological deficits. The levels of cyclic AMP in artery and IJV were 32.1 +/- 3.0 and 40.0 +/- 4.1 pmol/ml (means +/- standard errors), respectively, while those of cyclic GMP in artery and IJV were 12.2 +/- 2.7 and 14.4 +/- 3.0 pmol/ml, respectively. Concentrations of both cyclic nucleotides in IJV were significantly higher (P less than 0.001) than those in artery. IJV-arterial differences for cAMP and cGMP were 7.9 +/- 1.7 and 2.1 +/- 0.5 pmol/ml, respectively. The results indicate that both cyclic nucleotides are constantly produced and released from the normal human brain.

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