Human pial vascular reactions to intravenous Nimodipine-infusion during EC-IC bypass surgery. | Zendy

L. M. Auer | Zendy; Rainer Oberbauer | Zendy; H. van der Schalk | Zendy

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Human pial vascular reactions to intravenous Nimodipine-infusion during EC-IC bypass surgery.

Author(s) -

L. M. Auer,

Rainer Oberbauer,

H. van der Schalk

Publication year - 1983

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.14.2.210

Subject(s) - nimodipine , medicine , vasospasm , vasoconstriction , anesthesia , ischemia , subarachnoid hemorrhage , cerebral vasospasm , cardiology , calcium

In previous experimental work, the Ca-antagonist Nimodipine had shown a predominantly cerebroarterial dilatory effect. In the present double-blind study of 16 patients, pial arterial and venous reaction was investigated during EC-IC bypass surgery, infusing 1 microgram kg-1min-1 of Nimodipine intravenously. In pial arteries with resting diameters between 25 and 70 micrometers, a significant 18% dilatation was observed. Results are considered promising for future trials in the treatment and prevention of cerebral ischemia caused by vasoconstriction or vasospasm, especially vasospasm following subarachnoid hemorrhage.

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