Effect of mannitol on rCBF in canine thalamic ischemia--an experimental study. | Zendy

H Seki | Zendy; Takashi Yoshimoto | Zendy; Akiya Ogawa | Zendy; Jun Suzuki | Zendy

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Effect of mannitol on rCBF in canine thalamic ischemia--an experimental study.

Author(s) -

H Seki,

Takashi Yoshimoto,

Akiya Ogawa,

Jun Suzuki

Publication year - 1983

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.14.1.46

Subject(s) - mannitol , medicine , ischemia , osmotic concentration , thalamus , anesthesia , hemodynamics , infarction , carnivora , cardiology , myocardial infarction , radiology , chemistry , organic chemistry

Using the canine thalamic infarction model, we have investigated the effects of 10 ml/kg of 20% mannitol on the hemodynamics of the ischemic brain. Mannitol was found to cause an increase in rCBF, but it is not marked in animals with severe ischemic foci. Increases were statistically significant in the animals with moderate ischemia. Increases in rCBF due to mannitol administration lasted for about 1 hour, as did the rise in serum osmolarity. The actual relationship between these two parameters, remains unclear.

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