Effect of hypertension on blood-brain barrier. Change after restoration of blood flow in post-ischemic gerbil brains. An electronmicroscopic study. | Zendy

U. Ito | Zendy; K. Ohno | Zendy; T Yamaguchi | Zendy; H. Takei | Zendy; H. Tomita | Zendy; Yutaka Inaba | Zendy

Open Access

Effect of hypertension on blood-brain barrier. Change after restoration of blood flow in post-ischemic gerbil brains. An electronmicroscopic study.

Author(s) -

U. Ito,

K. Ohno,

T Yamaguchi,

H. Takei,

H. Tomita,

Yutaka Inaba

Publication year - 1980

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.11.6.606

Subject(s) - gerbil , medicine , ischemia , blood–brain barrier , blood flow , evans blue , horseradish peroxidase , brain ischemia , anesthesia , central nervous system , biochemistry , biology , enzyme

The effect of induced hypertension on the blood-brain barrier (BBB) change in Mongolian gerbils exposed to various periods of ischemia was studied. Evans blue dye was used to determine the BBB change in animals subjected to different levels of hypertension after 3 h ischemia. Horseradish peroxidase (HRP) was used in electronmicroscopic studies of animals subjected to 30 min, 1, 3 or 6 h ischemia and subsequently exposed for 30 min to varying periods and sequences of normo- and hypertension. Furthermore, HRP-labeled vesicle counts were performed in animals from the 30-min ischemia group. Our findings revealed that hypertension, after blood flow restoration following ischemia, induces and/or accelerates BBB damage by enhancing endothelial vesicular and/or tubulo-channel transport.

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