Intra-arterial nitroprusside treatment of acute experimental vasospasm. | Zendy

Leonard F. Hirsh | Zendy

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Intra-arterial nitroprusside treatment of acute experimental vasospasm.

Author(s) -

Leonard F. Hirsh

Publication year - 1980

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.11.6.601

Subject(s) - medicine , sodium nitroprusside , subarachnoid hemorrhage , vasospasm , basilar artery , anesthesia , intracranial pressure , cerebral vasospasm , blood pressure , cardiology , nitric oxide

The effect of intra-arterial sodium nitroprusside infusions on acute experimental basilar artery spasm was studied in dogs. Vasospasm produced by subarachnoid hemorrhage at normal intracranial pressure was partially relieved by nitroprusside. When given by the intra-arterial route, 15 times the recommended maximum intravenous does can be infused without significant hypotension or elevation in intracranial pressure.

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