Cerebral blood flow and edema following carotid occlusion in the gerbil. | Zendy

Alan Crockard | Zendy; Fausto Iannotti | Zendy; A T Hunstock | Zendy; Roger Smith | Zendy; Robert J. Harris | Zendy; L. Symon | Zendy

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Cerebral blood flow and edema following carotid occlusion in the gerbil.

Author(s) -

Alan Crockard,

Fausto Iannotti,

A T Hunstock,

Roger Smith,

Robert J. Harris,

L. Symon

Publication year - 1980

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.11.5.494

Subject(s) - medicine , cerebral blood flow , occlusion , edema , gerbil , blood flow , autoregulation , brain edema , anesthesia , cardiology , ischemia , blood pressure

A technique for measuring focal cerebral blood flow (CBF) and brain specific gravity (SG) in gerbils is described; CO2 reactivity and autoregulation were tested. The mean CBF was 29.5 +/- 4.5 ml/100 gm/min and brain SG 1.0500 +/- 0.0004. Unilateral carotid occlusion resulted in a reduction of flow to 12.8 +/- 5.8 ml/100 gm/min in the ipsilateral hemisphere with little change in the contraleteral hemisphere; there was also a decrease in brain SG. One hour after occlusion, brain edema, as judged by decreased SG, developed at CBF less than 20 ml/100 gm/min and reached maximal levels at 7 +/- 2 ml/100 gm/min. The amount of edema appeared to be related chiefly to the residual post-occlusion flow. With bilateral occlusion, CBF was close to zero and there was no change in SG, indicating that in the "no flow" situation, there is no edema.

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