Deleterious effect of glucose pretreatment on recovery from diffuse cerebral ischemia in the cat. II. Regional metabolite levels. | Zendy

Frank A. Welsh | Zendy; M. D. Ginsberg | Zendy; W Rieder | Zendy; William W. Budd | Zendy

Open Access

Deleterious effect of glucose pretreatment on recovery from diffuse cerebral ischemia in the cat. II. Regional metabolite levels.

Author(s) -

Frank A. Welsh,

M. D. Ginsberg,

W Rieder,

William W. Budd

Publication year - 1980

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.11.4.355

Subject(s) - phosphocreatine , medicine , ischemia , lactic acidosis , lactic acid , metabolite , cats , endocrinology , anesthesia , energy metabolism , biology , bacteria , genetics

Glucose was infused intravenously into cats prior to cerebral ischemia. Brain concentrations of glucose, measured in 7 regions, were elevated 2.5-fold compared to those of non-infused animals. Ischemia of 15 or 30 minutes duration caused a greater accumulation of lactic acid in the brain of glucose-infused animals. Post-ischemic restitution of cerebral ATP, phosphocreatine, and lactate during 90 minutes of recirculation was severely impaired in the brain of animals pretreated with glucose compared to untreated animals. Thus, excess lactic acidosis may be a major factor interfering with metabolic restitution following cerebral ischemia.

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