Enhancement of cerebrovascular effect of CO2 by hypoxia. | Zendy

Stephen R. Quint | Zendy; Oscar U. Scremin | Zendy; Ralph R. Sonnenschein | Zendy; Eduardo H. Rubinstein | Zendy

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Enhancement of cerebrovascular effect of CO2 by hypoxia.

Author(s) -

Stephen R. Quint,

Oscar U. Scremin,

Ralph R. Sonnenschein,

Eduardo H. Rubinstein

Publication year - 1980

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.11.3.286

Subject(s) - normocapnia , medicine , cerebral blood flow , anesthesia , hypoxia (environmental) , blood flow , blood pressure , halothane , hypercapnia , cardiology , oxygen , acidosis , chemistry , organic chemistry

Internal carotid blood flow, taken as an index of cerebral blood flow (CBF); arterial pressure; and respiratory O2 and CO2 concentrations, were measured in halothane (1%)-anesthetized, paralyzed and mechanically ventilated rabbits. CBF was determined at end-tidal CO2 of 4% (normocapnia) and 8%, as inspired O2 [O2]I) was varied stepwise over the range of 6.5 to 92%. Normocapnic CBF was constant over the range of 15 to 92% [O2]I, but it increased significantly to 240% and 380% of control when [O2]I was at 10% and 6.5%, respectively. Cerebrovascular response to CO2 was constant over the range of [O2]I tested, except for a significant elevation to 180% of control at [O2]I of 10%.

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