Regional cerebral blood flow in the rat as determined by particle distribution and by diffusible tracer. | Zendy

Roger W. Horton | Zendy; Timothy A. Pedley | Zendy; Brian S. Meldrum | Zendy

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Regional cerebral blood flow in the rat as determined by particle distribution and by diffusible tracer.

Author(s) -

Roger W. Horton,

Timothy A. Pedley,

Brian S. Meldrum

Publication year - 1980

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.11.1.39

Subject(s) - cerebral blood flow , pons , microsphere , medicine , cerebellum , striatum , tracer , blood flow , cerebral cortex , medulla oblongata , distribution (mathematics) , central nervous system , anatomy , anesthesia , dopamine , physics , mathematical analysis , mathematics , chemical engineering , nuclear physics , engineering

Measurements of total and regional cerebral blood flow in paralyzed rats maintained on 70% N2O/30% O2 obtained by a diffusible tracer technique, iodoantipyrine, and by a particle distribution method, microspheres, have been compared. Total CBF values were in good agreement, 0.86 +/- 0.07 ml/g/min (PaCO2 37.3 +/- 1.5, iodoantipyrine method) and 0.88 +/- 0.02 (PaCO2 36.2 +/- 0.8, microsphere method). Regional cerebral blood flows showed good agreement with the 2 methods, with highest flow in the colliculi, striatum and cerebral cortex and lowest flows in the hypothalamus, pons medulla and cerebellum. The iodoantipyrine method is technically easier to perform and had a higher precision.

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