Effect of phenobarbital on cerebral energy state and metabolism. Enzymatic activities. | Zendy

G. Benzi | Zendy; A. Agnoli | Zendy; F. Dagani | Zendy; Salvatore Ruggieri | Zendy; R. F. Villa | Zendy

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Effect of phenobarbital on cerebral energy state and metabolism. Enzymatic activities.

Author(s) -

G. Benzi,

A. Agnoli,

F. Dagani,

Salvatore Ruggieri,

R. F. Villa

Publication year - 1979

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.10.6.733

Subject(s) - phenobarbital , malate dehydrogenase , enzyme , biochemistry , succinate dehydrogenase , cytochrome c oxidase , medicine , citric acid cycle , citrate synthase , lactate dehydrogenase , biology

The changes induced by phenobarbital in cerebral enzymatic activities of the Krebs' cycle (citrate synthase, malate dehydrogenase) and electron transfer chain (total NADH-cytochrome c reductase and cytochrome oxidase) were studied. In addition, the activity of lactate dehydrogenase of acetylcholine esterase and of glutamate dehydrogenase was also studied. These enzymatic activities were evaluated in the homogenate in toto and in a crude mitochondrial fraction from rat brain. The modifications in some of these activities indicate that several new metabolic situations occur in brain tissue after phenobarbital treatment.

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