Small animal model for investigation of subarachnoid hemorrhage and cerebral vasospasm. | Zendy

Kevin J. Barry | Zendy; M A Gogjian | Zendy; B M Stein | Zendy

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Small animal model for investigation of subarachnoid hemorrhage and cerebral vasospasm.

Author(s) -

Kevin J. Barry,

M A Gogjian,

B M Stein

Publication year - 1979

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.10.5.538

Subject(s) - medicine , subarachnoid hemorrhage , subarachnoid space , vasospasm , basilar artery , cerebral vasospasm , animal model , anesthesia , surgery , cerebrospinal fluid

A method for induction of subarachnoid hemorrhage (SAH) in a rat model is described. Resolution of the hemorrhage was documented photographically and microscopically at intervals from 1 hr to 8 days. Photographs indicated that most of the hemorrhage was resorbed within 3 days, an observation confirmed microscopically by the amount of red blood cells in the subarachnoid space. Significant cerebral vasospasm was documented within the first 2 days after the induction of hemorrhage with the basilar artery returning to baseline values at an average of 3 days followed by moderate dilatation at 5 to 8 days. The suitability of the rat as an animal model for further investigation of subarachnoid hemorrhage is discussed.

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