Serum dopamine-beta-hydroxylase activity in acute stroke. | Zendy

Tadashi Kanda | Zendy; Fumio Gotoh | Zendy; Masahiro Yamamoto | Zendy; Fumihiko Sakai | Zendy; Tsuneyuki Takeoka | Zendy; Yoshihiko Takagi | Zendy

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Serum dopamine-beta-hydroxylase activity in acute stroke.

Author(s) -

Tadashi Kanda,

Fumio Gotoh,

Masahiro Yamamoto,

Fumihiko Sakai,

Tsuneyuki Takeoka,

Yoshihiko Takagi

Publication year - 1979

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.10.2.168

Subject(s) - medicine , stroke (engine) , blood pressure , venous blood , dopamine , endocrinology , anesthesia , mechanical engineering , engineering

Serum dopamine-beta-hydroxylase (DBH) activity was measured in 34 patients with acute cerebrovascular disease. The serum level of DBH activity showed its highest value soon after the onset of stroke and then gradually decreased over the next few days. After reaching its lowest level, the DBH activity again showed a slight increase. There was no direct relationship between serum DBH activity and total serum protein, or blood pressure. In 8 of 12 patients, DBH activity in the cerebral venous blood was higher than that in the arterial blood. These results suggest that rapid release of DBH into the circulating blood occurred after stroke, presumably from sympathetic nerve endings in the vessels or organs, including the brain.

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