The Effect of Isordil and Cyclospasmol on Vascular Spasm Induced in the Basilar Artery of the Cat | Zendy

M. S. Mahaley | Zendy; John P. Kapp | Zendy

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The Effect of Isordil and Cyclospasmol on Vascular Spasm Induced in the Basilar Artery of the Cat

Author(s) -

M. S. Mahaley,

John P. Kapp

Publication year - 1970

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.1.5.325

Subject(s) - medicine , basilar artery , vasospasm , subarachnoid hemorrhage , anesthesia , vasodilation , artery , cardiology , cerebral vasospasm , vasoconstriction

Vasospasm of the basilar artery of the cat was induced by subarachnoid bleeding and was observed by a transoral approach to the vessel. Intravenous Isordil (2 to 4 mg/kg) given following vasospasm produced vasodilatation with minimal arterial hypotension. Cyclospasmol, administered intravenously after vasospasm or orally prior to vasospasm, was ineffective in relieving or preventing basilar artery spasm.

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