Open AccessHyperoxic Exposure Leads to Nitrative Stress and Ensuing Microvascular Degeneration and Diminished Brain Mass and Function in the Immature Subject
Author(s) -
Mirna Sirinyan,
Florian Sennlaub,
Allison Dorfman,
Przemysław Sapieha,
Fernand Gobeil,
Pierre Hardy,
Pierre Lachapelle,
Sylvain Chemtob
Publication year - 2006
Publication title -
stroke
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.397
H-Index - 319
eISSN - 1524-4628
pISSN - 0039-2499
DOI - 10.1161/01.str.0000245082.19294.ff
Subject(s) - hyperoxia , medicine , enos , nitrotyrosine , endocrinology , nitric oxide , downregulation and upregulation , endothelial nos , cerebral cortex , superoxide dismutase , oxidative stress , nitric oxide synthase , lung , biology , biochemistry , gene
Neonates that survive very preterm birth have a high prevalence of cognitive impairment in later life. A common factor detected in premature infants is their postnatal exposure to high oxygen tension relative to that in utero. Hyperoxia is known to elicit injury to premature lung and retina. Because data on the exposure of the brain to hyperoxia are limited, we studied the effects of high oxygen on this tissue.
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