Na + /H + Exchanger Inhibitor, SM-20220, Is Protective Against Excitotoxicity in Cultured Cortical Neurons | Zendy

Yuji Matsumoto | Zendy; Seiji Yamamoto | Zendy; Y. Suzuki | Zendy; Takashi Tsuboi | Zendy; Susumu Terakawa | Zendy; Naohito Ohashi | Zendy; Kazuo Umemura | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Na ⁺ /H ⁺ Exchanger Inhibitor, SM-20220, Is Protective Against Excitotoxicity in Cultured Cortical Neurons

Author(s) -

Yuji Matsumoto,

Seiji Yamamoto,

Y. Suzuki,

Takashi Tsuboi,

Susumu Terakawa,

Naohito Ohashi,

Kazuo Umemura

Publication year - 2003

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.0000106910.42815.c2

Subject(s) - medicine , excitotoxicity , radiochemistry , glutamate receptor , receptor , chemistry

Recently, it has been reported that Na+/H+ exchanger (NHE) inhibitors demonstrated protective effects on ischemia/reperfusion brain injury in animal models. However, the mechanisms by which the neurons were protected against ischemic insult remain unclear. To reveal the cellular mechanism of the NHE inhibitor on the neuronal death, we examined the effects of a selective NHE inhibitor, SM-20220 (N-[aminoiminomethyl]-1-methyl-1H-indole-2-carboxamide methanesulfonate), on glutamate-induced neuronal death in rat cortical culture.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research