Open AccessNeuroprotection by Selective Nitric Oxide Synthase Inhibition at 24 Hours After Perinatal Hypoxia-Ischemia
Author(s) -
Cacha PeetersScholte,
Johanna G. Koster,
Wouter B. Veldhuis,
Evelyn van den Tweel,
Changlian Zhu,
Nicole Kops,
Klas Blomgren,
Dop Bär,
Sylvia van BuulOffers,
Henrik Hagberg,
Klaas Nicolay,
Frank van Bel,
Floris Groenendaal
Publication year - 2002
Publication title -
stroke
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.397
H-Index - 319
eISSN - 1524-4628
pISSN - 0039-2499
DOI - 10.1161/01.str.0000028343.25901.09
Subject(s) - medicine , neuroprotection , ischemia , nitric oxide , hypoxia (environmental) , nitric oxide synthase , tunel assay , anesthesia , pharmacology , cerebral hypoxia , apoptosis , endocrinology , biochemistry , biology , chemistry , oxygen , immunohistochemistry , organic chemistry
Perinatal hypoxia-ischemia is a major cause of neonatal morbidity and mortality. Until now no established neuroprotective intervention after perinatal hypoxia-ischemia has been available. The delay in cell death after perinatal hypoxia-ischemia creates possibilities for therapeutic intervention after the initial insult. Excessive nitric oxide and reactive oxygen species generated on hypoxia-ischemia and reperfusion play a key role in the neurotoxic cascade. The present study examines the neuroprotective properties of neuronal and inducible but not endothelial nitric oxide synthase inhibition by 2-iminobiotin in a piglet model of perinatal hypoxia-ischemia.
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