Mice Lacking the Vascular Endothelial Growth Factor-B Gene ( Vegfb ) Have Smaller Hearts, Dysfunctional Coronary Vasculature, and Impaired Recovery From Cardiac Ischemia | Zendy

Daniela Bellomo | Zendy; John P. Headrick | Zendy; Ginters Silins | Zendy; Carol Paterson | Zendy; Penny S. Thomas | Zendy; Michael G. Gartside | Zendy; Arne W. Mould | Zendy; Marian M. Cahill | Zendy; Ian D. Tonks | Zendy; Sean M. Grimmond | Zendy; Steve Townson | Zendy; Christine A. Wells | Zendy; Melissa H. Little | Zendy; Margaret C. Cummings | Zendy; Nicholas K. Hayward | Zendy; Graham F. Kay | Zendy

Open Access

Mice Lacking the Vascular Endothelial Growth Factor-B Gene ( Vegfb ) Have Smaller Hearts, Dysfunctional Coronary Vasculature, and Impaired Recovery From Cardiac Ischemia

Author(s) -

Daniela Bellomo,

John P. Headrick,

Ginters Silins,

Carol Paterson,

Penny S. Thomas,

Michael G. Gartside,

Arne W. Mould,

Marian M. Cahill,

Ian D. Tonks,

Sean M. Grimmond,

Steve Townson,

Christine A. Wells,

Melissa H. Little,

Margaret C. Cummings,

Nicholas K. Hayward,

Graham F. Kay

Publication year - 2000

Publication title -

circulation research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.899

H-Index - 336

eISSN - 1524-4571

pISSN - 0009-7330

DOI - 10.1161/01.res.86.2.e29

Subject(s) - angiogenesis , vascular endothelial growth factor b , vascular endothelial growth factor , knockout mouse , vascular endothelial growth factor a , vascular endothelial growth factor c , ischemia , medicine , biology , receptor , vegf receptors

Vascular endothelial growth factor-B (VEGF-B) is closely related to VEGF-A, an effector of blood vessel growth during development and disease and a strong candidate for angiogenic therapies. To further study the in vivo function of VEGF-B, we have generated Vegfb knockout mice (Vegfb(-/-)). Unlike Vegfa knockout mice, which die during embryogenesis, Vegfb(-/-) mice are healthy and fertile. Despite appearing overtly normal, Vegfb(-/-) hearts are reduced in size and display vascular dysfunction after coronary occlusion and impaired recovery from experimentally induced myocardial ischemia. These findings reveal a role for VEGF-B in the development or function of coronary vasculature and suggest potential clinical use in therapeutic angiogenesis.

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