Alteration of Cholesterol Metabolism in the Rat with Linoleic Acid

When linoleic acid is added to the diet of the rat there is an average increase in incorporation of radiocarbon into liver cholesterol of 259 per cent. By contrast, the addition of coconut oil to the diet does not increase the incorporation of radiocarbon into liver cholesterol. The addition of linoleic acid to a stock diet is associated with an increased fecal excretion of Liberman-Burchard chromogens, 3-β-hydroxy sterols and bile acids.