Effect of Histamine on the Pulmonary Circulation in Dogs | Zendy

O Storstein | Zendy; L. Cudkowicz | Zendy; H. D. Attwood | Zendy

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Effect of Histamine on the Pulmonary Circulation in Dogs

Author(s) -

O Storstein,

L. Cudkowicz,

H. D. Attwood

Publication year - 1959

Publication title -

circulation research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.899

H-Index - 336

eISSN - 1524-4571

pISSN - 0009-7330

DOI - 10.1161/01.res.7.3.360

Subject(s) - pulmonary artery , pulmonary wedge pressure , histamine , constriction , medicine , vascular resistance , cardiac output , blood pressure , cardiology , anesthesia , central venous pressure , respiration , heart rate , anatomy

Histamine was administered to dogs by the intravenous route near the right atrium in doses of 9.6 to 19 γ/Kg. body weight. It produced a severe drop in systemic blood pressure, negligible changes in heart rate and respiration, usually a fall in cardiac output and no change in left atrial or pulmonary artery wedge pressure. The pulmonary artery pressure showed an initial rise and then a fall following the drop in systemic blood pressure. Pulmonary arteriolar resistance followed the changes in cardiac output. There appeared to be no consistent evidence of pulmonary vascular constriction following the injection of histamine in the doses used in this study.

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