Influence of Gallogen and Diethanolamine Upon Induced Hypercholesterolemia in the Rat
Author(s) -
Seymour Dayton
Publication year - 1958
Publication title -
circulation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.899
H-Index - 336
eISSN - 1524-4571
pISSN - 0009-7330
DOI - 10.1161/01.res.6.3.271
Subject(s) - diethanolamine , chenodeoxycholic acid , cholic acid , cholesterol , chemistry , medicine , endocrinology , excretion , bile acid , biochemistry
The diethanolamine salt of the mono (α,p-dimethylbenzyl) ester of d-camphoric acid (Gallogen) augmented diet-induced hypercholesterolemia and hyperlipemia in the rat, while depressing liver cholesterol and total lipid concentrations. Diethanolamine had virtually identical effects. Gallogen, given orally to rats with biliary fistulas had a slight hydrocholeretic effect, but did not influence biliary excretion of cholesterol, cholic acid, or chenodeoxycholic acid.
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