Effect of Lung Denervation on Pulmonary Hypertension and Edema

Under conditions of high pulmonary artery pressure and flow produced in dogs by a controlled systemic artery shunt, pulmonary edema occurred after denervation of the lung at arterial pressures that were tolerated without edema before denervation. Left atrial pressures were not altered by the shunt, which involved only one segment of lung. Observation of animals with shunts for 1½ to 10 months showed that denervation apparently did not affect the incidence of arteriosclerosis.