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dium during coronary occlusion. Circ Res 26: 301-306, 1970 8. Rubio R, Wiedmeier VT, Berne RM: Relationship between coronary flow and adenosine production and release. J Mol Cell Cardiol 6:561566,1974 9. Fox AC, Reed GE, Glassman E, Kaltman AJ, Silk BB: Release of adenosine from human hearts during angina induced by rapid atria] pacing. J Clin Invest 53: 1447-1457, 1974 10. Somani P, Bachand RT Jr, Hardman HF, Laddu AR: Nutritional circulation in the heart. II. A reappraisal of the effect of nitroglycerin on myocardial hemodynamics, oxygen consumption and nutritional blood flow in the isolated supported heart preparation. Eur J Pharmacol 8: 1-13, 1969 11. Kalckar HM: Differential spectrophotometry of punne compounds by means of specific enzymes. I. Determination of hydroxypurine compounds. J Biol Chem 167: 429-443, 1947 12. Kalckar HM: Differential spectrophotometry of purine compound by means of specific enzymes. II. Determination of adenine compounds. J Biol Chem 167: 445-459, 1947 13. Berne RM: Effect of epinephrine and norepinephrine on coronary circulation. Circ Res 6: 644-655, 1958 14. Feinberg H, Katz LN: Effect of catecholamines, /-epinephrine and /norepinephrine on coronary flow and oxygen metabolism of the myocardium. Am J Physiol 193: 151-156, 1958 15. Lewis FB, Coffman JD, Gregg DE: Effect of heart rate and intracoronary isoproterenol, levarterenol and epinephrine on coronary flow and resistance. Circ Res 9: 89-95, 1961 16. Wegria R: Pharmacology of the coronary circulation. Pharmacol Rev 3: 197-246, 1951 17. Rubio R, Wiedmeier VT, Berne RM: Nucleoside phosphorylase; localization and role in the myocardial distribution of purines. Am i Physiol 222: 550-555, 1972 18. Flacke W, Atanackovic D, Gillis RA, Alper MH: The actions of histamine on the mammalian heart. J Pharmacol Exp Ther 155: 271278,1967 19. Levi R: Effects of exogenous and immunologically released histamine on the isolated heart. J Pharmacol Exp Ther 182: 227-238, 1972 20. Broadley KJ: The role of H, and H,-receptors in the coronary vascular response to histamine of isolated perfused hearts of guinea-pigs and rabbits. Br J Pharmacol 54: 511-521, 1975 21. Gross GJ, Hardman HG: Alteration in oxyhemoglobin equilibrium (P-50) and myocardial oxygen consumption (MVOS) by nitroglycerin. J Pharmacol Exp Ther 193: 346-355, 1975

Cholinergic intervention on myocardial dynamics and metabolism in the nonworking dog heart.