Cardiac Dilatation Without Hypertrophy from Reduced Ambient Pressure in Rats | Zendy

J. Clifford Stickney | Zendy; DAVID W. NORTHRUP | Zendy; Edward J. Van Liere | Zendy

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Cardiac Dilatation Without Hypertrophy from Reduced Ambient Pressure in Rats

Author(s) -

J. Clifford Stickney,

DAVID W. NORTHRUP,

Edward J. Van Liere

Publication year - 1956

Publication title -

circulation research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.899

H-Index - 336

eISSN - 1524-4571

pISSN - 0009-7330

DOI - 10.1161/01.res.4.2.217

Subject(s) - cardiac hypertrophy , muscle hypertrophy , medicine , cardiology , decompression , blood pressure , physiology

Short exposures of rats to greatly reduced ambient pressure after explosive decompression was found to result in cardiac dilatation. The dilatation, determined roentgenographically, was seen to persist for two or three days. Some rats were submitted to one long exposure, while others were repeatedly subjected to short exposures. Sacrifice of the rats sufficiently long after exposure to permit cardiac hypertrophy to develop revealed no evidence of it as determined from heart weightbody weight ratios.

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