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The abrupt rise in mean arterial pressure resulting from elimination of the moderator reflexes is not accompanied by a significant increase in cardiac output. The acute hypertension is therefore attributed to a severe generalized vasoconstriction. The severity of this vasomotor response progressively diminishes during the interval immediately following denervation.

The Acute Effects of Elimination of the Moderator Reflexes Upon Cardiac Output and Total Peripheral Resistance in the Anesthetized Dog