Studies on the Antithrombin and Heparin Co-factor Activities of a Fraction Adsorbed from Plasma by Aluminum Hydroxide | Zendy

Frank C. Monkhouse | Zendy; EVELYN S. FRANCE | Zendy; Walter H. Seegers | Zendy

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Studies on the Antithrombin and Heparin Co-factor Activities of a Fraction Adsorbed from Plasma by Aluminum Hydroxide

Author(s) -

Frank C. Monkhouse,

EVELYN S. FRANCE,

Walter H. Seegers

Publication year - 1955

Publication title -

circulation research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.899

H-Index - 336

eISSN - 1524-4571

pISSN - 0009-7330

DOI - 10.1161/01.res.3.4.397

Subject(s) - antithrombin , thrombin , chemistry , fibrinogen , heparin , thrombin time , chromatography , biochemistry , coagulation , medicine , platelet , partial thromboplastin time

A chemical method has been devised for the quantitative determination of plasma antithrombin. A concentrate of antithrombin has been prepared from plasma. It also contains heparin cofactor activity. The two distinct activities could not be separated and may quite possibly be the properties of a single substance. When the concentrate is combined with heparin the capacity of the concentrate to destroy thrombin is not increased but there is interference with the thrombin fibrinogen interaction. In a mixture of the concentrate and thrombin there is simultaneous destruction of antithrombin, and thrombin activities. Small amounts of the concentrate significantly prolong the clotting time of blood.

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