Effects of Epinephrine and Calcium on the Electrogram of the Ouabainized Frog Heart | Zendy

Walter W. Baker | Zendy; Judith M. Baker | Zendy

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Effects of Epinephrine and Calcium on the Electrogram of the Ouabainized Frog Heart

Author(s) -

Walter W. Baker,

Judith M. Baker

Publication year - 1955

Publication title -

circulation research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.899

H-Index - 336

eISSN - 1524-4571

pISSN - 0009-7330

DOI - 10.1161/01.res.3.3.274

Subject(s) - epinephrine , calcium , ouabain , ventricular fibrillation , medicine , atrial flutter , fibrillation , tachycardia , ventricular tachycardia , cardiology , endocrinology , chemistry , anesthesia , atrial fibrillation , sodium , organic chemistry

The effects of bound ouabain on the electrogram of the isolated frog heart are antagonized by epinephrine and potentiated by calcium. Ouabainized hearts also develop increased ventricular automatism (paroxysmal tachycardia, flutter and fibrillation) in the presence of large concentrations of calcium but not of epinephrine. The actions of both epinephrine and calcium are readily reversed by washing the tissue with normal Ringer's solution.

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