Protein-Lipid Relationships in Experimental Canine Atherosclerosis
Author(s) -
David P. Barr,
Ella M. Russ,
Howard A. Eder,
Forrest E. Kendall,
Liese L. Abell
Publication year - 1955
Publication title -
circulation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.899
H-Index - 336
eISSN - 1524-4571
pISSN - 0009-7330
DOI - 10.1161/01.res.3.2.199
Subject(s) - thiouracil , cholesterol , distribution (mathematics) , plasma lipoprotein , medicine , endocrinology , arteriosclerosis , lipoprotein , chemistry , biology , thyroid , mathematical analysis , mathematics
The applicability of Cohn's method number 10 to the study of dog plasma has made possible this investigation of experimental canine atherosclerosis. Administration of thiouracil which causes hypercholesterolemia but no atherosclerosis in dogs produces no considerable alteration in the distribution of plasma lipoproteins. High cholesterol feeding and administration of thiouracil causes both atherosclerosis and significant alterations in the distribution of lipoproteins.
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