Open AccessComparison of Antifibrillatory Potency of Certain Antimalarial Drugs with Quinidine and Procaine Amide
Author(s) -
FRANK BURNO,
Frank Burstein,
J R DiPalma
Publication year - 1954
Publication title -
circulation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.899
H-Index - 336
eISSN - 1524-4571
pISSN - 0009-7330
DOI - 10.1161/01.res.2.5.414
Subject(s) - quinidine , procainamide , potency , pharmacology , procaine , chemistry , medicine , anesthesia , in vitro , biochemistry
Using the method of electrical threshold of fibrillation in intact cats, it was found that quinacrine, chloroquine and pentaquine are very effective antifibrillatory agents. However, chlorguanide and Daraprim are ineffective. The significance of these findings is briefly discussed.
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