Effect of Adrenalectomy on Pressor Responsiveness to Angiotonin and Renin | Zendy

G. C. Salmoiraghi | Zendy; J. W. McCubbin | Zendy

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Effect of Adrenalectomy on Pressor Responsiveness to Angiotonin and Renin

Author(s) -

G. C. Salmoiraghi,

J. W. McCubbin

Publication year - 1954

Publication title -

circulation research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.899

H-Index - 336

eISSN - 1524-4571

pISSN - 0009-7330

DOI - 10.1161/01.res.2.3.280

Subject(s) - renin–angiotensin system , adrenalectomy , medicine , endogeny , pressor response , endocrinology , plasma renin activity , nephrectomy , kidney , blood pressure , heart rate

Pressor response to injection of renin is reduced or abolished during adrenal insufficiency without concurrent change in response to angiotonin and other drugs. Selective loss of response to renin is considered to result from depletion of available renin-substrate by endogenous renin; when release of endogenous renin is precluded by nephrectomy, adrenalectomy does not cause diminution of response to renin. The increase in response to angiotonin and renin that follows nephrectomy is not prevented by adrenalectomy.

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