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Infusion of cortisone and related compounds in the normal dog under standardized conditions resulted in increased voltage and peaking of the T wave of the electrocardiogram. These alterations were not associated with significant changes in the plasma electrolytes. Plasma inorganic phosphate decreased and urinary phosphate excretion increased. Cortisone appears to alter ventricular repolarization, but the mechanism of the effect is unknown.

Electrocardiographic Effects of Cortisone and Related Compounds on the Dog