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The spontaneous intake of water and saline and their output under load were measured in the early and late stages of perinephritic hypertension in rats. The conclusion was drawn that sodium exchange is increased in the prehypertensive phase, but reverts toward or drops below normal with the development of chronic sustained hypertension.

The Temporal Course of Fluid Intake and Response to Fluid Loads in Perinephritic Hypertension in Rats